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تعویض ترانس کاتتر دریچه آئورت
Metabolites could help time TAVR before LV damage is irreversible
Metabolites left from certain cellular processes may be markers of left ventricular (LV) remodeling and myocardial distress, as shown in patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis.
Blood samples taken immediately before and 24 hours after TAVR were used for metabolimic profiling via liquid chromatography and mass spectrometry.
Within 24 hours of TAVR, circulating levels of C16 decreased by 30.2%, C18:1 by 42.7%, C18:2 by 37.3%, and C18 by 38.3%, suggestive of an alleviation of cardiac pressure overload with the procedure.
"In symptomatic patients with severe aortic stenosis undergoing TAVR, circulating levels of long-chain acylcarnitines were independently associated with measures of maladaptive LV remodeling, and metabolic perturbations lessened after procedure completion," the authors concluded.
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